Release Date: 15 April 2012, USA

In 2094 a team of scientists follow anthropological clues across the galaxy to the Earth-like moon named LV223. On arrival, the scientists discover a huge, ancient complex with urns of a strange black material. The android David sneaks some of this material on board the ship and infects the scientist Halloway with it to see the effects. Halloway has sex with Shaw, who becomes pregnant with an alien aberration.

Returning to the alien complex, David breaks free from the group and discovers that one of the aliens is still alive in a statis chamber. After Halloway is consumed by the infection, the crew returns to the ship, and Shaw uses a MedPod device to manually extract the aberration growing in her womb. Despite the chaos, the believed-dead corporatist Peter Weyland comes out of hidden stasis on the ship, to reveal that the whole enterprise was arranged to let him make contact with the aliens and try to meet his makers and achieve immortality.

Back in the alien complex, David is decapitated and Weyland and his retinue killed by the furious, reanimated alien. The alien launches a spaceship from within the complex to complete his mission of heading to Earth and infecting it, but Captain Janek and crew crash Prometheus into his ship to save the Earth while sacrificing themselves. Shaw, the lone survivor, returns to an ejected life support pod only to find her alien spawn has grown to monstrous size. The furious alien, who has escaped his crashed ship and found the pod, tries to kill her, but she unlocks the MedPod room and escapes with the alien and the aberration locked in mortal combat. The decapitated but functional David contacts Shaw through radio, and informs her that there are other ships by which they can abandon the planet and return home.